Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is poorly understood how cortactin performs these functions. We describe the 2.89 Å resolution cryo-EM structure of cort...

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Detalles Bibliográficos
Autores principales: Fregoso, Fred E., Boczkowska, Malgorzata, Rebowski, Grzegorz, Carman, Peter J., van Eeuwen, Trevor, Dominguez, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613254/
https://www.ncbi.nlm.nih.gov/pubmed/37898612
http://dx.doi.org/10.1038/s41467-023-42229-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613254/
https://www.ncbi.nlm.nih.gov/pubmed/37898612
http://dx.doi.org/10.1038/s41467-023-42229-y

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