Amyloidogenic 60–71 deletion/ValThr insertion mutation of apolipoprotein A-I generates a new aggregation-prone segment that promotes nucleation through entropic effects

The N-terminal fragment of apolipoprotein A-I (apoA-I), comprising residues 1–83, contains three segments prone to aggregation: residues 14–22, 53–58, and 67–72. We previously demonstrated that residues 14–22 are critical in apoA-I fibril formation while residues 53–58 entropically drove the nucleat...

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Detalles Bibliográficos
Autores principales: Namba, Norihiro, Ohgita, Takashi, Tamagaki-Asahina, Hiroko, Nishitsuji, Kazuchika, Shimanouchi, Toshinori, Sato, Takeshi, Saito, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613298/
https://www.ncbi.nlm.nih.gov/pubmed/37898709
http://dx.doi.org/10.1038/s41598-023-45803-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613298/
https://www.ncbi.nlm.nih.gov/pubmed/37898709
http://dx.doi.org/10.1038/s41598-023-45803-y

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