Topological links in predicted protein complex structures reveal limitations of AlphaFold

AlphaFold is making great progress in protein structure prediction, not only for single-chain proteins but also for multi-chain protein complexes. When using AlphaFold-Multimer to predict protein‒protein complexes, we observed some unusual structures in which chains are looped around each other to f...

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Detalles Bibliográficos
Autores principales: Hou, Yingnan, Xie, Tengyu, He, Liuqing, Tao, Liang, Huang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613300/
https://www.ncbi.nlm.nih.gov/pubmed/37898666
http://dx.doi.org/10.1038/s42003-023-05489-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613300/
https://www.ncbi.nlm.nih.gov/pubmed/37898666
http://dx.doi.org/10.1038/s42003-023-05489-4

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