Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis

Aspirin and its active metabolite salicylate have emerged as promising agents for the chemoprevention of colorectal cancer (CRC). Moreover, aspirin suppresses the progression of established CRCs. However, the underlying molecular mechanisms are not completely understood. Here we found that salicylat...

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Detalles Bibliográficos
Autores principales: Liu, Chunfeng, Rokavec, Matjaz, Huang, Zekai, Hermeking, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613307/
https://www.ncbi.nlm.nih.gov/pubmed/37898661
http://dx.doi.org/10.1038/s41419-023-06226-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613307/
https://www.ncbi.nlm.nih.gov/pubmed/37898661
http://dx.doi.org/10.1038/s41419-023-06226-9

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