Cargando…
Salicylate induces AMPK and inhibits c-MYC to activate a NRF2/ARE/miR-34a/b/c cascade resulting in suppression of colorectal cancer metastasis
Aspirin and its active metabolite salicylate have emerged as promising agents for the chemoprevention of colorectal cancer (CRC). Moreover, aspirin suppresses the progression of established CRCs. However, the underlying molecular mechanisms are not completely understood. Here we found that salicylat...
Autores principales: | Liu, Chunfeng, Rokavec, Matjaz, Huang, Zekai, Hermeking, Heiko |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613307/ https://www.ncbi.nlm.nih.gov/pubmed/37898661 http://dx.doi.org/10.1038/s41419-023-06226-9 |
Ejemplares similares
-
Curcumin activates a ROS/KEAP1/NRF2/miR-34a/b/c cascade to suppress colorectal cancer metastasis
por: Liu, Chunfeng, et al.
Publicado: (2023) -
Meta-analysis of miR-34 target mRNAs using an integrative online application
por: Rokavec, Matjaz, et al.
Publicado: (2022) -
Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression
por: Du, Yuyun, et al.
Publicado: (2023) -
Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop
por: Li, Huihui, et al.
Publicado: (2015) -
miR-34a and IRE1A/XBP-1(S) Form a Double-Negative Feedback Loop to Regulate Hypoxia-Induced EMT, Metastasis, Chemo-Resistance and Autophagy
por: Bouznad, Nassim, et al.
Publicado: (2023)