The AMPK activator metformin improves recovery from demyelination by shifting oligodendrocyte bioenergetics and accelerating OPC differentiation

Multiple Sclerosis (MS) is a chronic disease characterized by immune-mediated destruction of myelinating oligodendroglia in the central nervous system. Loss of myelin leads to neurological dysfunction and, if myelin repair fails, neurodegeneration of the denuded axons. Virtually all treatments for M...

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Detalles Bibliográficos
Autores principales: Narine, Mohanlall, Azmi, Maryam A., Umali, Martin, Volz, Ashley, Colognato, Holly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613472/
https://www.ncbi.nlm.nih.gov/pubmed/37904733
http://dx.doi.org/10.3389/fncel.2023.1254303

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613472/
https://www.ncbi.nlm.nih.gov/pubmed/37904733
http://dx.doi.org/10.3389/fncel.2023.1254303

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