The synergy of the XPO1 inhibitors combined with the BET inhibitor INCB057643 in high-grade B-cell lymphoma via downregulation of MYC expression

High grade B-cell lymphoma with MYC and BCL2 rearrangements (HGBCL-DH) represents an uncommon B-cell lymphoma (BCL) with aggressive clinical courses and poor prognosis. Despite revolutionary therapeutic advances in BCL, there has been limited treatment progress in HGBCL-DH, thus necessitating additi...

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Detalles Bibliográficos
Autores principales: Deng, Manman, Tan, Jinshui, Fan, Ziying, Pham, Lan V., Zhu, Feng, Fang, Xiaosheng, Zhao, Haijun, Young, Kenh, Xu, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613613/
https://www.ncbi.nlm.nih.gov/pubmed/37899423
http://dx.doi.org/10.1038/s41598-023-45721-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613613/
https://www.ncbi.nlm.nih.gov/pubmed/37899423
http://dx.doi.org/10.1038/s41598-023-45721-z

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