TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease

BACKGROUND: TGFβ signaling appears to contribute to the pathogenesis of myxomatous mitral valve disease (MMVD) in both dogs and humans. However, little is known about the extent of the downstream signaling changes that will then affect cell phenotype and function in both species. OBJECTIVE: Identify...

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Detalles Bibliográficos
Autores principales: McNair, Andrew J., Markby, Greg R., Tang, Qiyu, MacRae, Vicky E., Corcoran, Brendan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613673/
https://www.ncbi.nlm.nih.gov/pubmed/37908840
http://dx.doi.org/10.3389/fvets.2023.1202001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613673/
https://www.ncbi.nlm.nih.gov/pubmed/37908840
http://dx.doi.org/10.3389/fvets.2023.1202001

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