Synthesis and evaluation of potent (iso)ellipticine-based inhibitors of MYLK4 accessed via expeditious synthesis from isoquinolin-5-ol

The K(2)S(2)O(8)-mediated generation of p-iminoquinone contributed to the regioselective substitution of isoquinolin-5,8-dione. This hydroxyl group-guided substitution was also applied to selected heterocycles and addressed the regioselectivity issue of quinones. This study has provided an expeditio...

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Detalles Bibliográficos
Autores principales: Lee, Szu, Chao, Min-Wu, Wu, Yi-Wen, Hsu, Chia-Min, Lin, Tony Eight, Hsu, Kai-Cheng, Pan, Shiow-Lin, Lee, Hsueh-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613853/
https://www.ncbi.nlm.nih.gov/pubmed/37908644
http://dx.doi.org/10.1039/d3ra06600b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10613853/
https://www.ncbi.nlm.nih.gov/pubmed/37908644
http://dx.doi.org/10.1039/d3ra06600b

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