Fighting Multidrug Resistance with Ruthenium–Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition

[Image: see text] The search for more effective and selective drugs to overcome cancer multidrug resistance is urgent. As such, a new series of ruthenium-cyclopentadienyl (“RuCp”) compounds with the general formula [Ru(η(5)-C(5)H(4)R)(4,4′-R′-2,2′-bipy)(PPh(3))] were prepared and fully characterized...

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Detalles Bibliográficos
Autores principales: Teixeira, Ricardo G., Salaroglio, Iris C., Oliveira, Nuno F. B., Sequeira, João G. N., Fontrodona, Xavier, Romero, Isabel, Machuqueiro, Miguel, Tomaz, Ana Isabel, Garcia, M. Helena, Riganti, Chiara, Valente, Andreia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614197/
https://www.ncbi.nlm.nih.gov/pubmed/37616241
http://dx.doi.org/10.1021/acs.jmedchem.3c01120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614197/
https://www.ncbi.nlm.nih.gov/pubmed/37616241
http://dx.doi.org/10.1021/acs.jmedchem.3c01120

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