Blockade of adenosine A(2A) receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

BACKGROUND: The over-activation of adenosine A(2A) receptors (A(2A)R) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A(2A)R blockade possesses neuroprotective effects on AD. Spatial navigation impairment is an early manifestation of cogni...

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Detalles Bibliográficos
Autores principales: Ji, Qi, Yang, Yang, Xiong, Yun, Zhang, Ying-Jie, Jiang, Jun, Zhou, Li-Ping, Du, Xiao-Hui, Wang, Chun-Xiang, Zhu, Zhi-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614339/
https://www.ncbi.nlm.nih.gov/pubmed/37899431
http://dx.doi.org/10.1186/s13195-023-01337-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614339/
https://www.ncbi.nlm.nih.gov/pubmed/37899431
http://dx.doi.org/10.1186/s13195-023-01337-z

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