Cargando…

Blockade of adenosine A(2A) receptors reverses early spatial memory defects in the APP/PS1 mouse model of Alzheimer’s disease by promoting synaptic plasticity of adult-born granule cells

BACKGROUND: The over-activation of adenosine A(2A) receptors (A(2A)R) is closely implicated in cognitive impairments of Alzheimer's disease (AD). Growing evidence shows that A(2A)R blockade possesses neuroprotective effects on AD. Spatial navigation impairment is an early manifestation of cogni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Qi, Yang, Yang, Xiong, Yun, Zhang, Ying-Jie, Jiang, Jun, Zhou, Li-Ping, Du, Xiao-Hui, Wang, Chun-Xiang, Zhu, Zhi-Ru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614339/ https://www.ncbi.nlm.nih.gov/pubmed/37899431 http://dx.doi.org/10.1186/s13195-023-01337-z

Ejemplares similares

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model
por: Kempf, Stefan J., et al.
Publicado: (2016)

Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A(2A) receptors
por: Viana da Silva, Silvia, et al.
Publicado: (2016)

The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model
por: Forest, Kelly H., et al.
Publicado: (2021)

Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease
por: Flores-Muñoz, Carolina, et al.
Publicado: (2020)

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice
por: Gengler, Simon, et al.
Publicado: (2010)

Novel Phenylethanoid Glycosides Improve Hippocampal Synaptic Plasticity via the Cyclic Adenosine Monophosphate-CREB-Brain-Derived Neurotrophic Growth Factor Pathway in APP/PS1 Transgenic Mice
por: Ji, Shiliang, et al.
Publicado: (2023)

Deficits in N-Methyl-D-Aspartate Receptor Function and Synaptic Plasticity in Hippocampal CA1 in APP/PS1 Mouse Model of Alzheimer’s Disease
por: Xu, Le, et al.
Publicado: (2021)

Excitability and Synaptic Alterations in the Cerebellum of APP/PS1 Mice
por: Hoxha, Eriola, et al.
Publicado: (2012)

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice
por: Mahaman, Yacoubou Abdoul Razak, et al.
Publicado: (2022)

Shenqi Xingnao Granules ameliorates cognitive impairments and Alzheimer’s disease-like pathologies in APP/PS1 mouse model
por: Yang, Cui-cui, et al.
Publicado: (2020)

Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition
por: Zhang, Jing-Hua, et al.
Publicado: (2018)

CART treatment improves memory and synaptic structure in APP/PS1 mice
por: Jin, Jia-li, et al.
Publicado: (2015)

Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Function and Synaptic Plasticity in APP23/PS45 Mouse Model of Alzheimer’s Disease
por: Huang, Zhilin, et al.
Publicado: (2017)

Neuropeptide S Ameliorates Cognitive Impairment of APP/PS1 Transgenic Mice by Promoting Synaptic Plasticity and Reducing Aβ Deposition
por: Zhao, Peng, et al.
Publicado: (2019)

Overexpression of LIMK1 in hippocampal excitatory neurons improves synaptic plasticity and social recognition memory in APP/PS1 mice
por: Zhang, Haiwang, et al.
Publicado: (2021)

ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice
por: Song, Leigang, et al.
Publicado: (2023)

TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease
por: Du, Yehong, et al.
Publicado: (2020)

Effects of Exercise Intensity on Spatial Memory Performance and Hippocampal Synaptic Plasticity in Transient Brain Ischemic Rats
por: Shih, Pei-Cheng, et al.
Publicado: (2013)

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
por: Torres, Manuel, et al.
Publicado: (2012)

Effect of adenosine on short‐term synaptic plasticity in mouse piriform cortex in vitro: adenosine acts as a high‐pass filter
por: Perrier, Simon P., et al.
Publicado: (2019)

Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer’s Disease
por: Gelman, Simon, et al.
Publicado: (2017)

Homeostatic Plasticity Studied Using In Vivo Hippocampal Activity-Blockade: Synaptic Scaling, Intrinsic Plasticity and Age-Dependence
por: Echegoyen, Julio, et al.
Publicado: (2007)

Hydrogen Sulfide Reverses Aging-Associated Amygdalar Synaptic Plasticity and Fear Memory Deficits in Rats
por: Zhan, Jin-Qiong, et al.
Publicado: (2018)

Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model
por: Nakatsuka, Daiki, et al.
Publicado: (2021)

NMDARs in granule cells contribute to parallel fiber–Purkinje cell synaptic plasticity and motor learning
por: Schonewille, Martijn, et al.
Publicado: (2021)

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
por: Lourenco, Mychael V., et al.
Publicado: (2019)

CRISPR/Cas9-mediated CysLT1R deletion reverses synaptic failure, amyloidosis and cognitive impairment in APP/PS1 mice
por: Chen, Fang, et al.
Publicado: (2021)

Hippocampal Insulin Resistance Impairs Spatial Learning and Synaptic Plasticity
por: Grillo, Claudia A., et al.
Publicado: (2015)

Inhibition of lysine methyltransferase G9a/GLP reinstates long-term synaptic plasticity and synaptic tagging/capture by facilitating protein synthesis in the hippocampal CA1 area of APP/PS1 mouse model of Alzheimer’s disease
por: Han, Javan Lee Tze, et al.
Publicado: (2021)

Synaptic Changes in the Dentate Gyrus of APP/PS1 Transgenic Mice Revealed by Electron Microscopy
por: Alonso-Nanclares, Lidia, et al.
Publicado: (2013)

Dendritic morphology, synaptic transmission, and activity of mature granule cells born following pilocarpine-induced status epilepticus in the rat
por: Gao, Fei, et al.
Publicado: (2015)

Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target
por: Szögi, Titanilla, et al.
Publicado: (2019)

Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer’s Disease APP/PS1 Mouse Model
por: Estévez-Silva, Héctor M., et al.
Publicado: (2022)

Adenosine A(2A) Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiking Interneurons of the Prefrontal Cortex
por: Kerkhofs, Amber, et al.
Publicado: (2018)

Lipopolysaccharide-Induced Spatial Memory and Synaptic Plasticity Impairment Is Preventable by Captopril
por: Abareshi, Azam, et al.
Publicado: (2016)

Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats
por: Arias-Cavieres, Alejandra, et al.
Publicado: (2018)

Spatial regulation of coordinated excitatory and inhibitory synaptic plasticity at dendritic synapses
por: Ravasenga, Tiziana, et al.
Publicado: (2022)

Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
por: Audrain, Mickael, et al.
Publicado: (2016)

Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions
por: Qiao, Ou, et al.
Publicado: (2021)

Tumor necrosis factor alpha maintains denervation-induced homeostatic synaptic plasticity of mouse dentate granule cells
por: Becker, Denise, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ji8mep7n3kk1b74r6gfvs4kdl0