Increased homozygosity due to endogamy results in fitness consequences in a human population

Recessive alleles have been shown to directly affect both human Mendelian disease phenotypes and complex traits. Pedigree studies also suggest that consanguinity results in increased childhood mortality and adverse health phenotypes, presumably through penetrance of recessive mutations. Here, we tes...

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Detalles Bibliográficos
Autores principales: Swinford, N. A., Prall, S. P., Gopalan, S., Williams, C. M., Sheehama, J., Scelza, B. A., Henn, B. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614605/
https://www.ncbi.nlm.nih.gov/pubmed/37847737
http://dx.doi.org/10.1073/pnas.2309552120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614605/
https://www.ncbi.nlm.nih.gov/pubmed/37847737
http://dx.doi.org/10.1073/pnas.2309552120

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