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Engineered oncolytic bacteria HCS1 exerts high immune stimulation and safety profiles for cancer therapy
Background and rationale: Attenuated Salmonella typhimurium VNP20009 has been used to treat tumor-bearing mice and entered phase I clinical trials. However, its mild anticancer effect in clinical trials may be related to insufficient bacterial colonization and notable adverse effects with increasing...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ivyspring International Publisher
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614684/ https://www.ncbi.nlm.nih.gov/pubmed/37908720 http://dx.doi.org/10.7150/thno.87340 |