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NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer’s disease pathology and cognitive outcomes

INTRODUCTION: Diffusion tensor imaging has been used to assess white matter (WM) changes in the early stages of Alzheimer’s disease (AD). However, the tensor model is necessarily limited by its assumptions. Neurite Orientation Dispersion and Density Imaging (NODDI) can offer insights into microstruc...

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Detalles Bibliográficos
Autores principales: Parker, Dana M., Adams, Jenna N., Kim, Soyun, McMillan, Liv, Yassa, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614746/
https://www.ncbi.nlm.nih.gov/pubmed/37905117
http://dx.doi.org/10.1101/2023.10.11.561946