Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

BACKGROUND AND AIMS: Activating mutations in the CTNNB1 gene encoding β-catenin are among the most frequently observed oncogenic alterations in hepatocellular carcinoma (HCC). HCC with CTNNB1 mutations show profound alterations in lipid metabolism including increases in fatty acid oxidation and tran...

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Detalles Bibliográficos
Autores principales: VanSant-Webb, Chad, Low, Hayden K., Kuramoto, Junko, Stanley, Claire E., Qiang, Hantao, Su, Audrey, Ross, Alexis N., Cooper, Chad G., Cox, James E., Summers, Scott A., Evason, Kimberley J., Ducker, Gregory S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614757/
https://www.ncbi.nlm.nih.gov/pubmed/37904922
http://dx.doi.org/10.1101/2023.10.12.562134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614757/
https://www.ncbi.nlm.nih.gov/pubmed/37904922
http://dx.doi.org/10.1101/2023.10.12.562134

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