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Development of covalent chemogenetic K(2P) channel activators

K(2P) potassium channels regulate excitability by affecting cellular resting membrane potential in the brain, cardiovascular system, immune cells, and sensory organs. Despite their important roles in anesthesia, arrhythmia, pain, hypertension, sleep, and migraine, the ability to control K(2P) functi...

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Detalles Bibliográficos
Autores principales: Deal, Parker E., Lee, Haerim, Mondal, Abhisek, Lolicato, Marco, de Mendonca, Philipe Ribeiro Furtado, Black, Holly, El-Hilali, Xochina, Bryant, Clifford, Isacoff, Ehud Y., Renslo, Adam R., Minor, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614804/
https://www.ncbi.nlm.nih.gov/pubmed/37905049
http://dx.doi.org/10.1101/2023.10.15.561774