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Bayesian inference of relative fitness on high-throughput pooled competition assays

The tracking of lineage frequencies via DNA barcode sequencing enables the quantification of microbial fitness. However, experimental noise coming from biotic and abiotic sources complicates the computation of a reliable inference. We present a Bayesian pipeline to infer relative microbial fitness f...

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Detalles Bibliográficos
Autores principales: Razo-Mejia, Manuel, Mani, Madhav, Petrov, Dmitri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614806/
https://www.ncbi.nlm.nih.gov/pubmed/37904971
http://dx.doi.org/10.1101/2023.10.14.562365
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author Razo-Mejia, Manuel
Mani, Madhav
Petrov, Dmitri
author_facet Razo-Mejia, Manuel
Mani, Madhav
Petrov, Dmitri
author_sort Razo-Mejia, Manuel
collection PubMed
description The tracking of lineage frequencies via DNA barcode sequencing enables the quantification of microbial fitness. However, experimental noise coming from biotic and abiotic sources complicates the computation of a reliable inference. We present a Bayesian pipeline to infer relative microbial fitness from high-throughput lineage tracking assays. Our model accounts for multiple sources of noise and propagates uncertainties throughout all parameters in a systematic way. Furthermore, using modern variational inference methods based on automatic differentiation, we are able to scale the inference to a large number of unique barcodes. We extend this core model to analyze multi-environment assays, replicate experiments, and barcodes linked to genotypes. On simulations, our method recovers known parameters within posterior credible intervals. This work provides a generalizable Bayesian framework to analyze lineage tracking experiments. The accompanying open-source software library enables the adoption of principled statistical methods in experimental evolution.
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spelling pubmed-106148062023-10-31 Bayesian inference of relative fitness on high-throughput pooled competition assays Razo-Mejia, Manuel Mani, Madhav Petrov, Dmitri bioRxiv Article The tracking of lineage frequencies via DNA barcode sequencing enables the quantification of microbial fitness. However, experimental noise coming from biotic and abiotic sources complicates the computation of a reliable inference. We present a Bayesian pipeline to infer relative microbial fitness from high-throughput lineage tracking assays. Our model accounts for multiple sources of noise and propagates uncertainties throughout all parameters in a systematic way. Furthermore, using modern variational inference methods based on automatic differentiation, we are able to scale the inference to a large number of unique barcodes. We extend this core model to analyze multi-environment assays, replicate experiments, and barcodes linked to genotypes. On simulations, our method recovers known parameters within posterior credible intervals. This work provides a generalizable Bayesian framework to analyze lineage tracking experiments. The accompanying open-source software library enables the adoption of principled statistical methods in experimental evolution. Cold Spring Harbor Laboratory 2023-10-18 /pmc/articles/PMC10614806/ /pubmed/37904971 http://dx.doi.org/10.1101/2023.10.14.562365 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Razo-Mejia, Manuel
Mani, Madhav
Petrov, Dmitri
Bayesian inference of relative fitness on high-throughput pooled competition assays
title Bayesian inference of relative fitness on high-throughput pooled competition assays
title_full Bayesian inference of relative fitness on high-throughput pooled competition assays
title_fullStr Bayesian inference of relative fitness on high-throughput pooled competition assays
title_full_unstemmed Bayesian inference of relative fitness on high-throughput pooled competition assays
title_short Bayesian inference of relative fitness on high-throughput pooled competition assays
title_sort bayesian inference of relative fitness on high-throughput pooled competition assays
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614806/
https://www.ncbi.nlm.nih.gov/pubmed/37904971
http://dx.doi.org/10.1101/2023.10.14.562365
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