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Computing the inducibility of B cell lineages under a context-dependent model of affinity maturation: Applications to sequential vaccine design
A key challenge in B cell lineage-based vaccine design is understanding the inducibility of target neutralizing antibodies. We approach this problem through the use of detailed stochastic modeling of the somatic hypermutation process that occurs during affinity maturation. Under such a model, sequen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614816/ https://www.ncbi.nlm.nih.gov/pubmed/37905016 http://dx.doi.org/10.1101/2023.10.13.562156 |