Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin

β-arrestins are multivalent adaptor proteins that bind active phosphorylated G protein-coupled receptors (GPCRs) to inhibit G protein signaling, mediate receptor internalization, and initiate alternative signaling events. β-arrestins link agonist-stimulated GPCRs to downstream signaling partners, su...

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Detalles Bibliográficos
Autores principales: Kahsai, Alem W., Shah, Kunal S., Shim, Paul J., Lee, Mason A., Shreiber, Bowie N., Schwalb, Allison M., Zhang, Xingdong, Kwon, Henry Y., Huang, Li-Yin, Soderblom, Erik J., Ahn, Seungkirl, Lefkowitz, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614829/
https://www.ncbi.nlm.nih.gov/pubmed/37844230
http://dx.doi.org/10.1073/pnas.2303794120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614829/
https://www.ncbi.nlm.nih.gov/pubmed/37844230
http://dx.doi.org/10.1073/pnas.2303794120

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