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Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction

Accurate chromosome segregation requires sister kinetochores to biorient, attaching to opposite spindle poles. To this end, the mammalian kinetochore destabilizes incorrect attachments and stabilizes correct ones, but how it discriminates between these is not yet clear. Here, we test the model that...

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Detalles Bibliográficos
Autores principales: Chong, Megan K., Rosas-Salvans, Miquel, Tran, Vanna, Dumont, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614862/
https://www.ncbi.nlm.nih.gov/pubmed/37905080
http://dx.doi.org/10.1101/2023.10.16.562637