CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs

Expansions of CAG trinucleotide repeats cause several rare neurodegenerative diseases. The disease-causing repeats are translated in multiple reading frames, without an identifiable initiation codon. The molecular mechanism of this repeat-associated non-AUG (RAN) translation is not known. We find th...

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Detalles Bibliográficos
Autores principales: Anderson, Rachel, Das, Michael, Chang, Yeonji, Farenhem, Kelsey, Jain, Ankur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614865/
https://www.ncbi.nlm.nih.gov/pubmed/37904984
http://dx.doi.org/10.1101/2023.10.16.562581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614865/
https://www.ncbi.nlm.nih.gov/pubmed/37904984
http://dx.doi.org/10.1101/2023.10.16.562581

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