Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells

The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor types. Determining regions of the KIF18A protein to target for inhibition will be important for the...

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Detalles Bibliográficos
Autores principales: Schutt, Katherine, Queen, Katelyn A., Fisher, Kira, Budington, Olivia, Mao, Weifeng, Liu, Wei, Xiao, Yisong, Aswad, Fred, Joseph, James, Stumpff, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614886/
https://www.ncbi.nlm.nih.gov/pubmed/37905069
http://dx.doi.org/10.1101/2023.10.16.562576

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614886/
https://www.ncbi.nlm.nih.gov/pubmed/37905069
http://dx.doi.org/10.1101/2023.10.16.562576

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