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Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells
The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor types. Determining regions of the KIF18A protein to target for inhibition will be important for the...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614886/ https://www.ncbi.nlm.nih.gov/pubmed/37905069 http://dx.doi.org/10.1101/2023.10.16.562576 |