Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells

Ribosomal DNA (rDNA) genes encode the structural RNAs of the ribosome and are present in hundreds of copies in mammalian genomes. Age-linked DNA hypermethylation throughout the rDNA constitutes a robust “methylation clock” that accurately reports age, yet the consequences of hypermethylation on rDNA...

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Detalles Bibliográficos
Autores principales: Blokhina, Yana, Buchwalter, Abigail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614900/
https://www.ncbi.nlm.nih.gov/pubmed/37904963
http://dx.doi.org/10.1101/2023.10.18.562830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614900/
https://www.ncbi.nlm.nih.gov/pubmed/37904963
http://dx.doi.org/10.1101/2023.10.18.562830

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