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Modeling the consequences of age-linked rDNA hypermethylation with dCas9-directed DNA methylation in human cells
Ribosomal DNA (rDNA) genes encode the structural RNAs of the ribosome and are present in hundreds of copies in mammalian genomes. Age-linked DNA hypermethylation throughout the rDNA constitutes a robust “methylation clock” that accurately reports age, yet the consequences of hypermethylation on rDNA...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614900/ https://www.ncbi.nlm.nih.gov/pubmed/37904963 http://dx.doi.org/10.1101/2023.10.18.562830 |