HDL regulates TGFß-receptor lipid raft partitioning, restoring contractile features of cholesterol-loaded vascular smooth muscle cells

BACKGROUND: Cholesterol-loading of mouse aortic vascular smooth muscle cells (mVSMCs) downregulates miR-143/145, a master regulator of the contractile state downstream of TGFβ signaling. In vitro, this results in transitioning from a contractile mVSMC to a macrophage-like state. This process likely...

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Detalles Bibliográficos
Autores principales: Nagesh, Prashanth Thevkar, Nishi, Hitoo, Rawal, Shruti, Zahr, Tarik, Miano, Joseph M., Sorci-Thomas, Mary, Xu, Hao, Akbar, Naveed, Choudhury, Robin P, Misra, Ashish, Fisher, Edward A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614922/
https://www.ncbi.nlm.nih.gov/pubmed/37905061
http://dx.doi.org/10.1101/2023.10.19.562786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614922/
https://www.ncbi.nlm.nih.gov/pubmed/37905061
http://dx.doi.org/10.1101/2023.10.19.562786

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