Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation

Sarcopenia burdens the elderly population through loss of muscle energy and mass, yet treatments to functionally rescue both parameters are missing. The glucocorticoid prednisone remodels muscle metabolism based on frequency of intake, but its mechanisms in sarcopenia are unknown. We found that once...

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Detalles Bibliográficos
Autores principales: Prabakaran, Ashok Daniel, McFarland, Kevin, Miz, Karen, Durumutla, Hima Bindu, Piczer, Kevin, El Abdellaoui Soussi, Fadoua, Latimer, Hannah, Werbrich, Cole, Blair, N. Scott, Millay, Douglas P, Prideaux, Brendan, Finck, Brian N, Quattrocelli, Mattia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614926/
https://www.ncbi.nlm.nih.gov/pubmed/37905062
http://dx.doi.org/10.1101/2023.10.16.562573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614926/
https://www.ncbi.nlm.nih.gov/pubmed/37905062
http://dx.doi.org/10.1101/2023.10.16.562573

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