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On the problem of inflation in transcriptome-wide association studies

Hundreds of thousands of loci have been associated with complex traits via genome-wide association studies (GWAS), but an understanding of the mechanistic connection between GWAS loci and disease remains elusive. Genetic predictors of molecular traits are useful for identifying the mediating roles o...

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Detalles Bibliográficos
Autores principales: Liang, Yanyu, Nyasimi, Festus, Im, Hae Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614931/
https://www.ncbi.nlm.nih.gov/pubmed/37904952
http://dx.doi.org/10.1101/2023.10.17.562831