Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes

Paclitaxel (PTX) is a hydrophobic small-molecule cancer drug that loads into the membrane (tail) region of lipid carriers such as liposomes and micelles. The development of improved lipid-based carriers of PTX is an important objective to generate chemotherapeutics with fewer side effects. The lipid...

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Detalles Bibliográficos
Autores principales: Steffes, Victoria, MacDonald, Scott, Crowe, John, Murali, Meena, Ewert, Kai K., Li, Youli, Safinya, Cyrus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614943/
https://www.ncbi.nlm.nih.gov/pubmed/37905081
http://dx.doi.org/10.1101/2023.10.18.563006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614943/
https://www.ncbi.nlm.nih.gov/pubmed/37905081
http://dx.doi.org/10.1101/2023.10.18.563006

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