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Lipids with negative spontaneous curvature decrease the solubility of the cancer drug paclitaxel in liposomes
Paclitaxel (PTX) is a hydrophobic small-molecule cancer drug that loads into the membrane (tail) region of lipid carriers such as liposomes and micelles. The development of improved lipid-based carriers of PTX is an important objective to generate chemotherapeutics with fewer side effects. The lipid...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614943/ https://www.ncbi.nlm.nih.gov/pubmed/37905081 http://dx.doi.org/10.1101/2023.10.18.563006 |