Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation

Targeted protein degradation with Proteolysis Targeting Chimeras (PROTACs) is a powerful therapeutic modality for eliminating disease-causing proteins through targeted ubiquitination and proteasome-mediated degradation. Most PROTACs have exploited substrate receptors of Cullin-RING E3 ubiquitin liga...

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Detalles Bibliográficos
Autores principales: Hong, Seong Ho, Osa, Akane, Huang, Oscar W., Wertz, Ingrid E., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614948/
https://www.ncbi.nlm.nih.gov/pubmed/37904950
http://dx.doi.org/10.1101/2023.10.20.563371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614948/
https://www.ncbi.nlm.nih.gov/pubmed/37904950
http://dx.doi.org/10.1101/2023.10.20.563371

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