TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery

Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiquitination of the key mitophagy regulator TBK1 is essential f...

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Detalles Bibliográficos
Autores principales: Saha, Bhaskar, Olsvik, Hallvard, Williams, Geneva L, Oh, Seeun, Evjen, Gry, Sjøttem, Eva, Mandell, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614974/
https://www.ncbi.nlm.nih.gov/pubmed/37905089
http://dx.doi.org/10.1101/2023.10.19.563195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614974/
https://www.ncbi.nlm.nih.gov/pubmed/37905089
http://dx.doi.org/10.1101/2023.10.19.563195

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