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Multi-pass, single-molecule nanopore reading of long protein strands with single-amino acid sensitivity

The ability to sequence single protein molecules in their native, full-length form would enable a more comprehensive understanding of proteomic diversity. Current technologies, however, are limited in achieving this goal. Here, we establish a method for long-range, single-molecule reading of intact...

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Detalles Bibliográficos
Autores principales: Motone, Keisuke, Kontogiorgos-Heintz, Daphne, Wee, Jasmine, Kurihara, Kyoko, Yang, Sangbeom, Roote, Gwendolin, Fang, Yishu, Cardozo, Nicolas, Nivala, Jeff
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614977/
https://www.ncbi.nlm.nih.gov/pubmed/37905023
http://dx.doi.org/10.1101/2023.10.19.563182