Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-(13)C]Pyruvate MR Spectroscopy

INTRODUCTION: The normal heart has remarkable metabolic flexibility that permits rapid switching between mitochondrial glucose oxidation and fatty acid (FA) oxidation to generate ATP. Loss of metabolic flexibility has been implicated in the genesis of contractile dysfunction seen in cardiomyopathy....

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Detalles Bibliográficos
Autores principales: Chen, Hsin-Yu, Gordon, Jeremy W., Dwork, Nicholas, Chung, Brian T., Riselli, Andrew, Sivalokanathan, Sanjay, Bok, Robert A., Slater, James B., Vigneron, Daniel B., Abraham, M. Roselle, Larson, Peder E.Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615004/
https://www.ncbi.nlm.nih.gov/pubmed/37905131
http://dx.doi.org/10.1101/2023.10.16.23297053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615004/
https://www.ncbi.nlm.nih.gov/pubmed/37905131
http://dx.doi.org/10.1101/2023.10.16.23297053

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