The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells

The mitotic regulator, Aurora kinase B (AURKB), is frequently overexpressed in malignancy and is a target for therapeutic intervention. The compound, LXY18, is a potent, orally available small molecule that inhibits the proper localization of AURKB during late mitosis, without affecting its kinase a...

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Detalles Bibliográficos
Autores principales: Kalashova, Julia, Yang, Chenglu, Li, Hongmei, Long, Yan, Yu, Duo, Zhang, Ting, Liu, Xumei, Choudhry, Namrta, Shi, Qiong, Allen, Thaddeus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615259/
https://www.ncbi.nlm.nih.gov/pubmed/37903144
http://dx.doi.org/10.1371/journal.pone.0293283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615259/
https://www.ncbi.nlm.nih.gov/pubmed/37903144
http://dx.doi.org/10.1371/journal.pone.0293283

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