Cargando…

Multi-ancestry meta-analysis and fine-mapping in Alzheimer’s disease

Genome-wide association studies (GWAS) of Alzheimer’s disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged published GWAS summary statistics from European, East Asian,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lake, Julie, Warly Solsberg, Caroline, Kim, Jonggeol Jeffrey, Acosta-Uribe, Juliana, Makarious, Mary B., Li, Zizheng, Levine, Kristin, Heutink, Peter, Alvarado, Chelsea X., Vitale, Dan, Kang, Sarang, Gim, Jungsoo, Lee, Kun Ho, Pina-Escudero, Stefanie D., Ferrucci, Luigi, Singleton, Andrew B., Blauwendraat, Cornelis, Nalls, Mike A., Yokoyama, Jennifer S., Leonard, Hampton L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615750/ https://www.ncbi.nlm.nih.gov/pubmed/37198259 http://dx.doi.org/10.1038/s41380-023-02089-w

Ejemplares similares

Genetic risk factor clustering within and across neurodegenerative diseases
por: Koretsky, Mathew J, et al.
Publicado: (2023)

Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors
por: Liu, Hui, et al.
Publicado: (2022)

omicSynth: an Open Multi-omic Community Resource for Identifying Druggable Targets across Neurodegenerative Diseases
por: Alvarado, Chelsea X., et al.
Publicado: (2023)

A population scale analysis of rare SNCA variation in the UK Biobank
por: Blauwendraat, Cornelis, et al.
Publicado: (2020)

The Parkinson's Disease DNA Variant Browser
por: Kim, Jonggeol J., et al.
Publicado: (2021)

Analysis of rare Parkinson’s disease variants in millions of people
por: Pitz, Vanessa, et al.
Publicado: (2023)

Coding and Noncoding Variation in LRRK2 and Parkinson's Disease Risk
por: Lake, Julie, et al.
Publicado: (2021)

Genome-wide case-only analysis of gene-gene interactions with known Parkinson’s disease risk variants reveals link between LRRK2 and SYT10
por: Aleknonytė-Resch, Milda, et al.
Publicado: (2023)

Human brain single nucleus cell type enrichments in neurodegenerative diseases
por: Alvarado, Chelsea X, et al.
Publicado: (2023)

Multi-modality machine learning predicting Parkinson’s disease
por: Makarious, Mary B., et al.
Publicado: (2022)

Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
por: Towns, Clodagh, et al.
Publicado: (2023)

Investigation of Autosomal Genetic Sex Differences in Parkinson's Disease
por: Blauwendraat, Cornelis, et al.
Publicado: (2021)

The Parkinson's Disease Genome‐Wide Association Study Locus Browser
por: Grenn, Francis P., et al.
Publicado: (2020)

Accelerating Medicines Partnership: Parkinson's Disease. Genetic Resource
por: Iwaki, Hirotaka, et al.
Publicado: (2021)

PTPA variants and the risk for Parkinson’s disease in diverse ancestry populations
por: Ostrožovičová, Miriam, et al.
Publicado: (2023)

Genetics of NLRP3 suggests lack of involvement and inefficient druggability in Parkinson’s disease
por: Senkevich, Konstantin, et al.
Publicado: (2023)

Bidirectional relationship between olfaction and Parkinson’s disease
por: Kim, Jonggeol J., et al.
Publicado: (2023)

Federated Learning for multi-omics: a performance evaluation in Parkinson’s disease
por: Danek, Benjamin, et al.
Publicado: (2023)

Identification and prediction of Parkinson’s disease subtypes and progression using machine learning in two cohorts
por: Dadu, Anant, et al.
Publicado: (2022)

Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer’s Disease Across Two Brain Regions
por: Belonwu, Stella A., et al.
Publicado: (2021)

LPEseq: Local-Pooled-Error Test for RNA Sequencing Experiments with a Small Number of Replicates
por: Gim, Jungsoo, et al.
Publicado: (2016)

A comparative investigation of variant calling and genotyping for a single non-Caucasian whole genome
por: Park, HyeonSeul, et al.
Publicado: (2023)

Multimodal Neuroimaging Predictors of Gait Decline
por: Sargent, Lana, et al.
Publicado: (2020)

RIC3 variants are not associated with Parkinson’s disease in large European, Latin American, or East Asian cohorts
por: Brolin, Kajsa, et al.
Publicado: (2022)

Exploring the genetic and genomic connection underlying neurodegeneration with brain iron accumulation and the risk for Parkinson’s disease
por: Alvarez Jerez, Pilar, et al.
Publicado: (2023)

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
por: Sirkis, Daniel W., et al.
Publicado: (2023)

Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations
por: Tang, Alice S., et al.
Publicado: (2022)

Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer’s Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions
por: Belonwu, Stella A., et al.
Publicado: (2022)

Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma
por: Shin, Won-Sik, et al.
Publicado: (2018)

Genetic and Transcriptomic Biomarkers in Neurodegenerative Diseases: Current Situation and the Road Ahead
por: Lake, Julie, et al.
Publicado: (2021)

Functionalization of the TMEM175 p.M393T variant as a risk factor for Parkinson disease
por: Jinn, Sarah, et al.
Publicado: (2019)

NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations
por: Bandres-Ciga, Sara, et al.
Publicado: (2023)

The Parkinson's Disease Mendelian Randomization Research Portal
por: Noyce, Alastair J., et al.
Publicado: (2019)

Unhealthy Behaviours and Risk of Parkinson’s Disease: A Mendelian Randomisation Study
por: Heilbron, Karl, et al.
Publicado: (2021)

Fishing for ancestry
por: Brunsdon, Hannah, et al.
Publicado: (2018)

The Ancestry of Chalicotherium
por: Osborn, Henry F.
Publicado: (1892)

What is ancestry?
por: Mathieson, Iain, et al.
Publicado: (2020)

Differentiation of Hispanic biogeographic ancestry with 80 ancestry informative markers
por: Setser, Casandra H., et al.
Publicado: (2020)

Genetic Ancestry Has the Same Major Problems as Phenotypic Ancestry
por: Burney, Peter
Publicado: (2022)

Comprehensive promoter level expression quantitative trait loci analysis of the human frontal lobe
por: Blauwendraat, Cornelis, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_fit93224hadnuabmsau95m9vkt