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Contextual fear memory impairment in Angelman syndrome model mice is associated with altered transcriptional responses

Angelman syndrome (AS) is a rare neurogenetic disorder caused by UBE3A deficiency and characterized by severe developmental delay, cognitive impairment, and motor dysfunction. In the present study, we performed RNA-seq on hippocampal samples from both wildtype (WT) and AS male mice, with or without...

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Detalles Bibliográficos
Autores principales: Su, Wenyue, Liu, Yan, Lam, Aileen, Hao, Xiaoning, Baudry, Michel, Bi, Xiaoning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616231/
https://www.ncbi.nlm.nih.gov/pubmed/37903805
http://dx.doi.org/10.1038/s41598-023-45769-x