Protection of eIF2B from inhibitory phosphorylated eIF2: A viral strategy to maintain mRNA translation during the PKR-triggered integrated stress response

The integrated stress response (ISR) protects cells from a variety of insults. Once elicited (e.g., by virus infections), it eventually leads to the block of mRNA translation. Central to the ISR are the interactions between translation initiation factors eIF2 and eIF2B. Under normal conditions, eIF2...

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Detalles Bibliográficos
Autores principales: Ito, Takuhiro, Wuerth, Jennifer Deborah, Weber, Friedemann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616414/
https://www.ncbi.nlm.nih.gov/pubmed/37742919
http://dx.doi.org/10.1016/j.jbc.2023.105287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616414/
https://www.ncbi.nlm.nih.gov/pubmed/37742919
http://dx.doi.org/10.1016/j.jbc.2023.105287

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