Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines

The manuscript describes the highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working s...

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Autores principales: Naikoo, Rayees Ahmad, Kumar, Rupesh, Sharma, Rashmi, Mahajan, Dinesh, Bhargava, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616752/
https://www.ncbi.nlm.nih.gov/pubmed/37915442
http://dx.doi.org/10.1039/d3ra05651a
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author Naikoo, Rayees Ahmad
Kumar, Rupesh
Sharma, Rashmi
Mahajan, Dinesh
Bhargava, Gaurav
author_facet Naikoo, Rayees Ahmad
Kumar, Rupesh
Sharma, Rashmi
Mahajan, Dinesh
Bhargava, Gaurav
author_sort Naikoo, Rayees Ahmad
collection PubMed
description The manuscript describes the highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working successfully with different substrates. The synthesis of functionalized pteridines is of great significance because of their potential pharmacological profile.
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spelling pubmed-106167522023-11-01 Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines Naikoo, Rayees Ahmad Kumar, Rupesh Sharma, Rashmi Mahajan, Dinesh Bhargava, Gaurav RSC Adv Chemistry The manuscript describes the highly regioselective 6-exo-dig iodo/bromo cyclization of functionalized N-propagyl-amino-pyrimidinones under ambient conditions. The cyclization afforded functionalized pteridines in excellent yields. The optimized procedures are mild, operationally simple and working successfully with different substrates. The synthesis of functionalized pteridines is of great significance because of their potential pharmacological profile. The Royal Society of Chemistry 2023-10-31 /pmc/articles/PMC10616752/ /pubmed/37915442 http://dx.doi.org/10.1039/d3ra05651a Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Naikoo, Rayees Ahmad
Kumar, Rupesh
Sharma, Rashmi
Mahajan, Dinesh
Bhargava, Gaurav
Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
title Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
title_full Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
title_fullStr Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
title_full_unstemmed Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
title_short Highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
title_sort highly regioselective 6-exo-dig iodo/bromo cyclizations of functionalized 5-amino propargyl pyrimidinones: an efficient synthesis of functionalized pteridines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616752/
https://www.ncbi.nlm.nih.gov/pubmed/37915442
http://dx.doi.org/10.1039/d3ra05651a
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