Directing the Stereoselectivity of the Claisen Rearrangement to Form Cyclic Ketones with Full Substitution at the α-Positions

[Image: see text] We report an enantioselective synthesis of cyclic ketones with full substitutions at the α-positions in a highly diastereoselective manner. Our method is achieved by subjecting substrate motifs in 2-allyloxyenones to chiral organomagnesium reagents, which trigger the Claisen rearra...

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Detalles Bibliográficos
Autores principales: Badmus, Fatimat O., Thombal, Raju S., Philkhana, Satish Chandra, Malone, Joshua A., Bailey, Christian E., Armendariz-Gonzalez, Estefania, Mureka, Edward W., Locicero, Cale M., Fronczek, Frank R., Kartika, Rendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616857/
https://www.ncbi.nlm.nih.gov/pubmed/37830497
http://dx.doi.org/10.1021/acs.orglett.3c02752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616857/
https://www.ncbi.nlm.nih.gov/pubmed/37830497
http://dx.doi.org/10.1021/acs.orglett.3c02752

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