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Directing the Stereoselectivity of the Claisen Rearrangement to Form Cyclic Ketones with Full Substitution at the α-Positions
[Image: see text] We report an enantioselective synthesis of cyclic ketones with full substitutions at the α-positions in a highly diastereoselective manner. Our method is achieved by subjecting substrate motifs in 2-allyloxyenones to chiral organomagnesium reagents, which trigger the Claisen rearra...
Autores principales: | Badmus, Fatimat O., Thombal, Raju S., Philkhana, Satish Chandra, Malone, Joshua A., Bailey, Christian E., Armendariz-Gonzalez, Estefania, Mureka, Edward W., Locicero, Cale M., Fronczek, Frank R., Kartika, Rendy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10616857/ https://www.ncbi.nlm.nih.gov/pubmed/37830497 http://dx.doi.org/10.1021/acs.orglett.3c02752 |
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