Deletion of the gene for the African swine fever virus BCL-2 family member A179L increases virus uptake and apoptosis but decreases virus spread in macrophages and reduces virulence in pigs

The African swine fever virus (ASFV) encodes inhibitors of innate immune responses, including type I interferon and apoptosis. The BCL-2 family A179L gene was deleted from the virulent genotype I isolate Benin 97/1. In infected macrophages, this resulted in increased caspase 3 and 7 activities, Anne...

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Detalles Bibliográficos
Autores principales: Reis, Ana Luisa, Rathakrishnan, Anusyah, Goulding, Leah V., Barber, Claire, Goatley, Lynnette C., Dixon, Linda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617521/
https://www.ncbi.nlm.nih.gov/pubmed/37796125
http://dx.doi.org/10.1128/jvi.01106-23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617521/
https://www.ncbi.nlm.nih.gov/pubmed/37796125
http://dx.doi.org/10.1128/jvi.01106-23

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