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Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3

The Rho family GTPases Rac and Rho play critical roles in transmitting mechanical information contained within the extracellular matrix (ECM) to the cell. Rac and Rho have well-described roles in regulating stiffness-dependent actin remodeling, proliferation and motility. However, much less is known...

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Detalles Bibliográficos
Autores principales: Dang, Irène, Brazzo, Joseph A., Bae, Yongho, Assoian, Richard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617619/
https://www.ncbi.nlm.nih.gov/pubmed/37737020
http://dx.doi.org/10.1242/jcs.260636