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The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression

Viruses use microRNAs (miRNAs) to impair the host antiviral response and facilitate viral infection by expressing their own miRNAs or co-opting cellular miRNAs. miRNAs inhibit translation initiation of their target mRNAs by recruiting the GIGYF2–4EHP (or EIF4E2) translation repressor complex to the...

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Detalles Bibliográficos
Autores principales: Naeli, Parisa, Zhang, Xu, Snell, Patric Harris, Chatterjee, Susanta, Kamran, Muhammad, Ladak, Reese Jalal, Orr, Nick, Duchaine, Thomas, Sonenberg, Nahum, Jafarnejad, Seyed Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617620/
https://www.ncbi.nlm.nih.gov/pubmed/37732428
http://dx.doi.org/10.1242/jcs.261286