CAG repeat expansion in the Huntington’s disease gene shapes linear and circular RNAs biogenesis

Alternative splicing (AS) appears to be altered in Huntington’s disease (HD), but its significance for early, pre-symptomatic disease stages has not been inspected. Here, taking advantage of Htt CAG knock-in mouse in vitro and in vivo models, we demonstrate a correlation between Htt CAG repeat lengt...

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Detalles Bibliográficos
Autores principales: Ayyildiz, Dilara, Bergonzoni, Guendalina, Monziani, Alan, Tripathi, Takshashila, Döring, Jessica, Kerschbamer, Emanuela, Di Leva, Francesca, Pennati, Elia, Donini, Luisa, Kovalenko, Marina, Zasso, Jacopo, Conti, Luciano, Wheeler, Vanessa C., Dieterich, Christoph, Piazza, Silvano, Dassi, Erik, Biagioli, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617732/
https://www.ncbi.nlm.nih.gov/pubmed/37831730
http://dx.doi.org/10.1371/journal.pgen.1010988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617732/
https://www.ncbi.nlm.nih.gov/pubmed/37831730
http://dx.doi.org/10.1371/journal.pgen.1010988

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