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Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer
Although subsets of patients with lung squamous cell carcinoma (LSCC) benefit from immunotherapy, there are few effective molecularly targeted treatments for LSCC. Fibroblast growth factor receptor (FGFR) inhibitors provide a therapeutic option for patients with LSCC harboring FGFR aberrations, but...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617760/ https://www.ncbi.nlm.nih.gov/pubmed/37909331 http://dx.doi.org/10.1172/JCI174171 |
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author | Mäkinen, Netta Meyerson, Matthew |
author_facet | Mäkinen, Netta Meyerson, Matthew |
author_sort | Mäkinen, Netta |
collection | PubMed |
description | Although subsets of patients with lung squamous cell carcinoma (LSCC) benefit from immunotherapy, there are few effective molecularly targeted treatments for LSCC. Fibroblast growth factor receptor (FGFR) inhibitors provide a therapeutic option for patients with LSCC harboring FGFR aberrations, but their therapeutic efficacy has been limited to date. In this issue of the JCI, Malchers et al. identified tail-to-tail rearrangements, either within or near FGFR1, that are associated with FGFR1 dependency and sensitivity to FGFR inhibition in LSCC. These results may help improve the selection of patients with LSCC who are most likely to benefit from treatment with FGFR inhibitors. |
format | Online Article Text |
id | pubmed-10617760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Society for Clinical Investigation |
record_format | MEDLINE/PubMed |
spelling | pubmed-106177602023-11-01 Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer Mäkinen, Netta Meyerson, Matthew J Clin Invest Commentary Although subsets of patients with lung squamous cell carcinoma (LSCC) benefit from immunotherapy, there are few effective molecularly targeted treatments for LSCC. Fibroblast growth factor receptor (FGFR) inhibitors provide a therapeutic option for patients with LSCC harboring FGFR aberrations, but their therapeutic efficacy has been limited to date. In this issue of the JCI, Malchers et al. identified tail-to-tail rearrangements, either within or near FGFR1, that are associated with FGFR1 dependency and sensitivity to FGFR inhibition in LSCC. These results may help improve the selection of patients with LSCC who are most likely to benefit from treatment with FGFR inhibitors. American Society for Clinical Investigation 2023-11-01 /pmc/articles/PMC10617760/ /pubmed/37909331 http://dx.doi.org/10.1172/JCI174171 Text en © 2023 Mäkinen, et al. https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Commentary Mäkinen, Netta Meyerson, Matthew Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer |
title | Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer |
title_full | Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer |
title_fullStr | Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer |
title_full_unstemmed | Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer |
title_short | Genomic insights into the mechanisms of FGFR1 dependency in squamous cell lung cancer |
title_sort | genomic insights into the mechanisms of fgfr1 dependency in squamous cell lung cancer |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617760/ https://www.ncbi.nlm.nih.gov/pubmed/37909331 http://dx.doi.org/10.1172/JCI174171 |
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