Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer

The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplification (detected by FISH) responded to FGFR kinase inhibitor trea...

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Detalles Bibliográficos
Autores principales: Malchers, Florian, Nogova, Lucia, van Attekum, Martijn H.A., Maas, Lukas, Brägelmann, Johannes, Bartenhagen, Christoph, Girard, Luc, Bosco, Graziella, Dahmen, Ilona, Michels, Sebastian, Weeden, Clare E., Scheel, Andreas H., Meder, Lydia, Golfmann, Kristina, Schuldt, Philipp, Siemanowski, Janna, Rehker, Jan, Merkelbach-Bruse, Sabine, Menon, Roopika, Gautschi, Oliver, Heuckmann, Johannes M., Brambilla, Elisabeth, Asselin-Labat, Marie-Liesse, Persigehl, Thorsten, Minna, John D., Walczak, Henning, Ullrich, Roland T., Fischer, Matthias, Reinhardt, Hans Christian, Wolf, Jürgen, Büttner, Reinhard, Peifer, Martin, George, Julie, Thomas, Roman K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617767/
https://www.ncbi.nlm.nih.gov/pubmed/37606995
http://dx.doi.org/10.1172/JCI170217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617767/
https://www.ncbi.nlm.nih.gov/pubmed/37606995
http://dx.doi.org/10.1172/JCI170217

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