DUSP8 induces TGF-β–stimulated IL-9 transcription and Th9-mediated allergic inflammation by promoting nuclear export of Pur-α

Dual-specificity phosphatase 8 (DUSP8) is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. DUSP8 is highly expressed in T cells; however, the in vivo role of DUSP8 in T cells remains unclear. Using T cell–specific Dusp8 conditional KO (T-Dusp8 cKO) mice, mass spectrometry ana...

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Detalles Bibliográficos
Autores principales: Chuang, Huai-Chia, Hsueh, Chia-Hsin, Hsu, Pu-Ming, Tsai, Ching-Yi, Shih, Ying-Chun, Chiu, Hsien-Yi, Chen, Yi-Ming, Yu, Wen-Kuang, Chen, Ming-Han, Tan, Tse-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617771/
https://www.ncbi.nlm.nih.gov/pubmed/37909329
http://dx.doi.org/10.1172/JCI166269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617771/
https://www.ncbi.nlm.nih.gov/pubmed/37909329
http://dx.doi.org/10.1172/JCI166269

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