CD8(+) T cells recognizing a neuron-restricted antigen injure axons in a model of multiple sclerosis

CD8(+) T cells outnumber CD4(+) cells in multiple sclerosis (MS) lesions associated with disease progression, but the pathogenic role and antigenic targets of these clonally expanded effectors are unknown. Based on evidence that demyelination is necessary but not sufficient for disease progression i...

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Detalles Bibliográficos
Autores principales: Clarkson, Benjamin D.S., Grund, Ethan M., Standiford, Miranda M., Mirchia, Kanish, Westphal, Maria S., Muschler, Liz S., Howe, Charles L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617772/
https://www.ncbi.nlm.nih.gov/pubmed/37676734
http://dx.doi.org/10.1172/JCI162788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10617772/
https://www.ncbi.nlm.nih.gov/pubmed/37676734
http://dx.doi.org/10.1172/JCI162788

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